In this study, we observed reduced effective connectivity in resting-state functional magnetic resonance imaging between key networks involved in attention and interoception in melancholia. We propose that these abnormalities underlie the impoverished variety and affective quality of internally generated thought in this disorder:
Hyett MP, Breakspear M, Friston KJ, Guo, CC, Parker G (2015). Disrupted effective connectivity of cortical systems supporting attention and interoception in melancholia. JAMA Psychiatry 72: 350-358.