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Time-resolved resting-state brain networks

posted Jun 30, 2014, 12:52 PM by Michael Breakspear   [ updated Jun 30, 2014, 12:53 PM ]
Large-scale organizational properties of brain networks mapped with functional magnetic resonance imaging have been studied in a time-averaged sense. This is an oversimplification. We demonstrate that brain activity between multiple pairs of spatially distributed regions spontaneously fluctuates in and out of correlation over time in a globally coordinated manner, giving rise to sporadic intervals during which information can be efficiently exchanged between neuronal populations. We argue that dynamic fluctuations in the brain’s organizational properties may minimize metabolic requirements while maintaining the brain in a responsive state.